Exercise intolerance is one of the most challenging and expensive problems facing any healthcare system. The CPET solution provided by MET-TEST takes a multi-organ, systematic approach to tackling this difficult problem. MET-TEST effectively reproduces the data collection and interpretation processes developed by Dr. Karlman Wasserman and colleagues at Harbor-UCLA (1), one of the most respected exercise physiology laboratories in the world. The primary purpose of the baseline CPET is to establish peak VO2 as a cardiac vital sign and to determine the etiology of exercise impairment. The reason for stopping exercise is the source of exercise intolerance and hence symptoms. This information can then be used to pinpoint more precise therapies. If the therapy is effective, then the patient's exercise capacity will increase and can be objectively verified with serial testing. If there are multiple reasons for exercise intolerance as is common in clinical practice, a step-wise approach can be used to identify the primary cause of exercise intolerance and prioritize the appropriate therapies in proper sequence to ensure that the desired goal of alleviating symptoms and restoring exercise capacity is attained. 

Over 18 years of extensive testing in community based clinics, MET-TEST has developed a systematic approach in the evaluation and treatment of patients with exercise intolerance. This approach is field tested and proven to be clinically effective in the real world. It heralds an era of customized therapy based upon individual physiological responses of patients during exercise.

Cardiopulmnary exercise testing (CPET)  provides a novel and purely physiological basis to identify cardiac dysfunction in symptomatic patients with both obstructive-CAD and nonobstructive-CAD (NO-CAD) . In many cases, abnormal cardiac response on CPET may be the only objective evidence of potentially undertreated ischemic heart disease. When symptomatic patients have NO-CAD on coronary angiogram, they are still at increased risk for cardiovascular events. This problem appears to be more common in women than men and may warrant more aggressive risk factor modification. As the main intervention is lifestyle (diet, smoking cessation,  exercise) and medical therapy (statins, angiotensin-converting enzyme inhibitors, beta-blockers), serial CPET  testing enables close surveillance of cardiovascular function and is responsive to clinical status.1

1. A practical clinical approach to utilize cardiopulmonary exercise testing in the evaluation and management of coronary artery disease: a primer for cardiologists -  Copyright - 2017 The Author(s). Published by Wolters Kluwer Health, Inc.